Biomarker
DNAm PhenoAge
Executive intelligence snapshot
Current reviewed view
Risk stratification and observational state characterization in validated populations
This profile includes 0 reviewed relationship(s) and 4 reviewed source(s).
This view is bounded by reviewed evidence and does not provide a recommendation or a claim beyond the stated review date.
Evidence state
Source-reviewed
Evidence state
What the evidence supports
Risk stratification and observational state characterization in validated populations
Evidence boundary
Key limitations
- Validated intervention endpoint, treatment selector, clinical utility, or surrogate endpoint
Does not establish efficacy, mechanism falsification, approval, utility, rejuvenation, or investment attractiveness.
Not established
Key unknowns
- Clinical utility, treatment-selection utility, surrogate validity, portability, and unreviewed post-freeze evidence remain unknown unless explicitly supported.
The reviewed evidence does not resolve this dimension beyond the recorded boundary.
Intelligence connections
Related intelligence
No reviewed related intelligence is recorded for this profile. No relationship is inferred.
Reviewed source layer
Evidence & sources
These cards show only metadata present in the reviewed source registry.
bibliographic index
An epigenetic biomarker of aging for lifespan and healthspan
PubMed / U.S. National Library of Medicine
Reference: PMID 29676998; bounded citation metadata and abstract review via NCBI E-utilities
Reviewed: 2026-08-06
bibliographic index
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial
PubMed / U.S. National Library of Medicine
Reference: PMID 37118425; bounded citation metadata and abstract review via NCBI E-utilities
Reviewed: 2026-08-06
trial registry
CALERIE: Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy
ClinicalTrials.gov / U.S. National Library of Medicine
Reference: ClinicalTrials.gov record NCT00427193; exact API observation
Reviewed: 2026-08-06
bibliographic index
Technical reproducibility does not ensure biological reliability of epigenetic clocks
PubMed / U.S. National Library of Medicine
Reference: PMID 42525215; bounded citation metadata and abstract review via NCBI E-utilities
Reviewed: 2026-08-06
Evidence update
Pending review
Further evidence review is pending.
Technical provenance
- Object key
biomarker:dnam_phenoage- Source release
LNPG-REL-20260807-027- Mapping version
0.2.0- Presentation release
LNPG-REL-20260808-037- Projection hash
c88b2800943bb4d4064c2f4904c32c6ab607868fc779575c5f396187813de25a
Source identifiers
LNPG-SRC-670d5250-3fb6-4f57-a40d-ce4165f88499LNPG-SRC-8681fbd3-62ce-4c28-ba69-16d57d4519b3LNPG-SRC-95f9ff1c-e459-4ba5-8096-15b3646cf699LNPG-SRC-ef9dc515-599a-461e-947a-840630f3c1bb
Directed relationship identities
No directed relationship identity is recorded.
Scores are not displayed because no score methodology is qualified for this profile.
Presentation contract
- Snapshot mode
DIRECT_GOVERNED_SUMMARY
Pending-state records
pending:00003—accepted_downstream_pending_context
Exposed separately; canonical facts unchanged.pending:00004—accepted_downstream_pending_context
Exposed separately; canonical facts unchanged.