Biomarker
DunedinPoAm and DunedinPACE
Executive intelligence snapshot
Current reviewed view
Pace-of-aging estimation, longitudinal research and intervention-response measurement in studied contexts
This profile includes 0 reviewed relationship(s) and 5 reviewed source(s).
This view is bounded by reviewed evidence and does not provide a recommendation or a claim beyond the stated review date.
Evidence state
Source-reviewed
Evidence state
What the evidence supports
Pace-of-aging estimation, longitudinal research and intervention-response measurement in studied contexts
Evidence boundary
Key limitations
- Clinical benefit, treatment selection or validated surrogate use
Does not establish efficacy, mechanism falsification, approval, utility, rejuvenation, or investment attractiveness.
Not established
Key unknowns
- Clinical utility, treatment-selection utility, surrogate validity, portability, and unreviewed post-freeze evidence remain unknown unless explicitly supported.
The reviewed evidence does not resolve this dimension beyond the recorded boundary.
Intelligence connections
Related intelligence
No reviewed related intelligence is recorded for this profile. No relationship is inferred.
Reviewed source layer
Evidence & sources
These cards show only metadata present in the reviewed source registry.
bibliographic index
Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm
PubMed / U.S. National Library of Medicine
Reference: PMID 32367804; bounded citation metadata and abstract review via NCBI E-utilities
Reviewed: 2026-08-06
bibliographic index
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial
PubMed / U.S. National Library of Medicine
Reference: PMID 37118425; bounded citation metadata and abstract review via NCBI E-utilities
Reviewed: 2026-08-06
trial registry
CALERIE: Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy
ClinicalTrials.gov / U.S. National Library of Medicine
Reference: ClinicalTrials.gov record NCT00427193; exact API observation
Reviewed: 2026-08-06
bibliographic index
Technical reproducibility does not ensure biological reliability of epigenetic clocks
PubMed / U.S. National Library of Medicine
Reference: PMID 42525215; bounded citation metadata and abstract review via NCBI E-utilities
Reviewed: 2026-08-06
bibliographic index
DunedinPACE, a DNA methylation biomarker of the pace of aging
PubMed / U.S. National Library of Medicine
Reference: PMID 35029144; bounded citation metadata and abstract review via NCBI E-utilities
Reviewed: 2026-08-06
Evidence update
Pending review
Further evidence review is pending.
Technical provenance
- Object key
biomarker:dunedin_pace- Source release
LNPG-REL-20260807-027- Mapping version
0.2.0- Presentation release
LNPG-REL-20260808-037- Projection hash
3a8b0b1b1389c9954cdba5e25dc7738d84e2d953014bad620ed2b0ceb9ef1b48
Source identifiers
LNPG-SRC-4e650dab-b521-4ddf-8355-a69494f79f66LNPG-SRC-8681fbd3-62ce-4c28-ba69-16d57d4519b3LNPG-SRC-95f9ff1c-e459-4ba5-8096-15b3646cf699LNPG-SRC-ef9dc515-599a-461e-947a-840630f3c1bbLNPG-SRC-f0c641fd-59fa-4ccd-9555-d6034bbe1db0
Directed relationship identities
No directed relationship identity is recorded.
Scores are not displayed because no score methodology is qualified for this profile.
Presentation contract
- Snapshot mode
DIRECT_GOVERNED_SUMMARY
Pending-state records
pending:00005—accepted_downstream_pending_context
Exposed separately; canonical facts unchanged.pending:00006—accepted_downstream_pending_context
Exposed separately; canonical facts unchanged.