LongevityNext

Biomarker

Horvath pan-tissue epigenetic clock

Source-reviewedGoverned LongevityNext intelligence profile
Evidence reviewed through2026-08-07

Executive intelligence snapshot

Current reviewed view

Chronological-age estimation within studied assay contexts; exploratory intervention-response measurement

This profile includes 0 reviewed relationship(s) and 3 reviewed source(s).

This view is bounded by reviewed evidence and does not provide a recommendation or a claim beyond the stated review date.

Evidence state

Source-reviewed

Evidence reviewed through2026-08-07

Evidence state

What the evidence supports

Chronological-age estimation within studied assay contexts; exploratory intervention-response measurement

Evidence boundary

Key limitations

  • Clinical benefit, lifespan extension, treatment selection, or biological-age reversal from a lower predicted value

    Does not establish efficacy, mechanism falsification, approval, utility, rejuvenation, or investment attractiveness.

Not established

Key unknowns

  • Clinical utility, treatment-selection utility, surrogate validity, portability, and unreviewed post-freeze evidence remain unknown unless explicitly supported.

    The reviewed evidence does not resolve this dimension beyond the recorded boundary.

Next evidence milestone

What would change this view?

A preregistered multisite intervention study linking durable clock change to patient-relevant outcomes

Evidence reviewed through 2026-08-07.

Intelligence connections

No reviewed related intelligence is recorded for this profile. No relationship is inferred.

Reviewed source layer

Evidence & sources

These cards show only metadata present in the reviewed source registry.

Evidence update

Pending review

Further evidence review is pending.

Technical provenance
Object key
biomarker:horvath_pan_tissue
Source release
LNPG-REL-20260807-027
Mapping version
0.2.0
Presentation release
LNPG-REL-20260808-037
Projection hash
e0097aaf40bbda892c0f5d9aaaa87c2d573921d516ced03af684b384b4d0cd63

Source identifiers

  • LNPG-SRC-280fed56-d326-4ad3-81e0-85f1f05cd5c1
  • LNPG-SRC-5da18483-1431-4b0e-85fd-0d66e1338cff
  • LNPG-SRC-ef9dc515-599a-461e-947a-840630f3c1bb

Directed relationship identities

No directed relationship identity is recorded.

Scores are not displayed because no score methodology is qualified for this profile.

Presentation contract

Snapshot mode
DIRECT_GOVERNED_SUMMARY

Pending-state records

  • pending:00013 — accepted_downstream_pending_context
    Exposed separately; canonical facts unchanged.
Opens in a new tab