Intervention

L-tryptophan, nicotinic acid, and nicotinamide

Source-reviewedGoverned LongevityNext intelligence profile

Evidence reviewed through2026-08-07

Executive intelligence snapshot

Current reviewed view

The publication reported no mitochondrial or skeletal-muscle function improvement, while the registry separately records early operational termination after COVID-19 disruption.

This profile includes 2 reviewed relationship(s) and 2 reviewed source(s).

This view is bounded by reviewed evidence and does not provide a recommendation or a claim beyond the stated review date.

Evidence state

Source-reviewed

Evidence reviewed through2026-08-07

Evidence state

What the evidence supports

The publication reported no mitochondrial or skeletal-muscle function improvement, while the registry separately records early operational termination after COVID-19 disruption.

Evidence boundary

Key limitations

The small study and its COVID-related early stop do not exclude effects from other NAD precursors, doses, durations, or populations.
Does not establish efficacy, mechanism falsification, approval, utility, rejuvenation, or investment attractiveness.

Not established

Key unknowns

Dose, route, population, and outcomes not recorded in this reviewed profile remain unknown.
The reviewed evidence does not resolve this dimension beyond the recorded boundary.

Next evidence milestone

What would change this view?

No specific evidence milestone is recorded yet.

Evidence reviewed through 2026-08-07.

Intelligence connections

Linked company

Maastricht University

Company

Tested in

NAD-precursor combination in physically compromised older adults

Trial

Reviewed source layer

Evidence & sources

These cards show only metadata present in the reviewed source registry.

trial registry

NAD Supplementation Study in Physically Compromised Older Adults

ClinicalTrials.gov

Reference: NCT03310034

Reviewed: 2026-08-06

bibliographic index

NAD+-Precursor Supplementation Does Not Improve Mitochondrial or Skeletal Muscle Function in Physically Compromised Older Adults

PubMed

Reference: 34191033

Reviewed: 2026-08-06

Technical provenance

Object key: intervention:LNPG-ENT-8c524e5c-d9a1-422a-8895-09d67f4ca2d8
Source release: LNPG-REL-20260807-027
Mapping version: 0.2.0
Presentation release: LNPG-REL-20260808-037
Projection hash: 176f65c36768b3b68a546c805ec846754c8aefa402ac376f06c1c23567059197

Source identifiers

LNPG-SRC-2123dfdc-71ef-4efa-a5d5-900ece47358e
LNPG-SRC-2146e2fb-d1e2-436e-98b7-e514464a9968

Directed relationship identities

edge:00185 — intervention_exactly_links_company
edge:00186 — intervention_tested_in_trial

Scores are not displayed because no score methodology is qualified for this profile.

Presentation contract

Snapshot mode: DIRECT_GOVERNED_SUMMARY